With low levels of serotonin you’ll experience the worry-type of anxiety with ruminations, obsessing, panic attacks, insomnia (often lying awake worrying). He talks about the type of cell in the gut that produces serotonin – the enterochromaffin cell – and the fact that “ spore forming bacteria are some of the best stimulators of the enterochromaffin cell to produce serotonin.” He reminds us about the gut-brain connection and how anxiety and mental health issues come from the gut “ because the vast majority of serotonin in your body – more than ninety percent of it – is actually produced in the gut” and not in the brain. coagulans MTCC 5856 as an important new treatment option for major depressive disorder in IBS patients.ĭuring The Anxiety Summit 5: Gut-Brain Axis, I interviewed Kiran Krishnan who is a microbiologist, one of the founders of Microbiome Labs and a co-creator of MegaSporeBiotic™. The improvement in depression and IBS symptoms was statistically significant and clinically meaningful. It was a randomised, double-blind, placebo controlled, multi-centre, pilot clinical study and: In one study, Bacillus coagulans (one of the spore-forming strains in MegaSporeBiotic™), when used alone was shown to help ease depression and gut problems in IBS patients. Pretreatment with probiotic spore-forming Bacillus strains and a supplement of amino acids in combination with immunoglobulins exhibited anti-inflammatory and antioxidant effects in an AA-induced rat model of ulcerative colitis. Probiotic Bacillus Spores Together with Amino Acids and Immunoglobulins Exert Protective Effects on a Rat Model of Ulcerative Colitis.Intoxication with acetaminophen is the main cause of acute liver toxicity in both the US and Europe.” This is important because “Acetaminophen is one of the most used analgesics and antipyretic agents in the world. Probiotic Bacillus Spores Protect Against Acetaminophen Induced Acute Liver Injury in Rats.The results demonstrated that patients treated with MegaSporeBiotic, compared with those treated with rifaximin followed by nutraceutical or low-FODMAP diet, had similar severity scores and rectal volume sensation test results for all parameters tested and statistically significant improvement in measurements of quality of life. Spores-A Promising Treatment Option for Patients with Irritable Bowel Syndrome The key findings of the present study is that oral spore-based probiotic supplementation reduced symptoms indicative of “leaky gut syndrome”. Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers.Here are some of the studies supporting this spore-based probiotic for gut issues: Given the gut-brain connection and the fact that the majority of serotonin is produced in the gut, it’s not surprising that spore-based probiotics may also help ease anxiety and depression. Research and clinical results show it is promising for irritable bowel syndrome (IBS) or SIBO (small intestinal bacterial overgrowth), recovery from liver injury caused by acetaminophen, and is protective in ulcerative colitis (an inflammatory bowel disease). MegaSporeBiotic™ is “a 100% spore-based broad-spectrum probiotic shown to maintain healthy gut barrier function” i.e.
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